Major depressive disorder (MDD), commonly known as depression, affects over 300 million
people worldwide as of 2018 and presents a wide range of clinical symptoms. The …

Introduction Non-motor symptoms (NMS) affect patients with Parkinson's disease (PD) from
the prodromal to the advanced stages. NMS phenotypes greatly vary and have a huge …

Patients with treatment-resistant depression (TRD) have higher rates of relapse and
pronounced decreases in daily functioning and health-related quality of life compared to …

N-methyl-d-aspartate receptors (NMDARs) are members of the glutamate receptor family
and participate in excitatory postsynaptic transmission throughout the central nervous …

Glutamate activates the NMDARs, significantly affecting multiple processes such as
learning, memory, synaptic integration, and excitatory transmission in the central nervous …

Objective To review the usefulness of esketamine for treatment-resistant depression. Method
Pivotal trials of intranasal esketamine in treatment-resistant depression were synthesized as …

The open-channel block of N-methyl-D-aspartate receptors (NMDARs) and their calcium-
dependent desensitization (CDD) represent conventional mechanisms of glutamatergic …

All definitions of treatment-resistant depression (TRD) require that patients have
experienced insufficient benefit from one or more adequate antidepressant trials. Thus …

Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal
calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N …

Depressive disorders pose significant challenges to global public health, necessitating
effective prevention and management strategies. Notably, the occurrence of suicide …