Schizophrenia is a debilitating mental illness which involves three groups of symptoms, ie,
positive, negative and cognitive, and has major public health implications. According to …

Background Previous research has investigated the efficacy of clozapine in reducing
suicidality in patients with schizophrenia and schizoaffective disorder. We aimed to …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

Context A long-standing version of the dopamine hypothesis of schizophrenia postulates
that hyperactivity of dopaminergic transmission at D 2 receptors in the limbic striatum is …

OBJECTIVE: Research has implicated dysfunction of glutamatergic neurotransmission in the
pathophysiology of schizophrenia. This review evaluates evidence from preclinical and …

Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date …

Atypical antipsychotics have greatly enhanced the treatment of schizophrenia. The
mechanisms underlying the effectiveness and adverse effects of these drugs are, to date, not …

The fundamental pathological process (es) associated with schizophrenia remain (s)
uncertain, but multiple lines of evidence suggest that this condition is associated with (1) …

This chapter is an update on the dopamine (DA) imbalance in schizophrenia, including the
evidence for subcortical hyperstimulation of D2 receptors underlying positive symptoms and …

Schizophrenia is a common and debilitating illness, characterized by chronic psychotic
symptoms and psychosocial impairment that exact considerable human and economic …