While continuous manufacturing (CM) of pharmaceutical solid-based drug products has
been shown to be advantageous for improving the product quality and process efficiency in …

Optimized physical properties (eg, bulk, surface/interfacial, and mechanical properties) of
active pharmaceutical ingredients (APIs) are key to the successful integration of drug …

Residence time distributions (RTDs) are quickly becoming an important component of the
quality control strategy for continuous manufacturing (CM) of pharmaceutical products …

This study investigates the usefulness of machine learning for modeling complex
relationships in a material library. We tested 81 types of active pharmaceutical ingredients …

In this paper, the material library approach was used to uncover the pattern of tabletability
change and related risk for tablet formulation design under the roll compaction and dry …

The production of pharmaceutical tablets is shifting towards continuous manufacturing.
Therefore, individual unit operations such as powder blending need to be re-designed …

The tablet manufacturing process is a complex system, especially in continuous
manufacturing (CM). It includes multiple unit operations, such as mixing, granulation, and …

Powder feeding is of critical importance for continuous manufacturing (CM) since next to in-
process segregation it is the phenomenon primarily responsible for fluctuations in content …

Segregation is a common problem in batch-based direct compression (BDC) processes,
especially with low-dose tablet products, as is the preparation of a homogenous mixture …

This study developed a material and time saving method for powder characterization.
Building on an earlier developed raw material property database for use towards …