Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

K Nepali, S Sharma, M Sharma, PMS Bedi… - European journal of …, 2014 - Elsevier
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill.

AG Durán, MT Gutiérrez, FJR Mejías, JMG Molinillo… - Molecules, 2021 - mdpi.com
Annona cherimola Mill., or the custard apple, is one of the species belonging to the
Annonaceae family, is widely used in traditional medicine, and has been reported to be a …

Proximate composition, phytochemical analysis, and in vitro antioxidant potentials of extracts of Annona muricata (Soursop)

KC Agu, PN Okolie - Food science & nutrition, 2017 - Wiley Online Library
Numerous bioactive compounds and phytochemicals have been reported to be present
Annona muricata (Soursop). Some of these chemical compounds have been linked to the …

[HTML][HTML] In vitro anticancer assessments of Annona muricata fractions and in vitro antioxidant profile of fractions and isolated acetogenin (15-acetyl guanacone)

KC Agu, NP Okolie, A Falodun, N Engel-Lutz - Journal of Cancer Research …, 2018 - Elsevier
Annona muricata has been attributed with numerous health benefits–including anticancer
properties. The aim of this study was to carry out anticancer investigations of fractions of …

Natural insecticides from the Annonaceae: a unique example for developing biopesticides

MB Isman, R Seffrin - Advances in plant biopesticides, 2014 - Springer
The documented negative impacts of synthetic insecticides on the environment as well as on
human health, the consumers' concerns over insecticide residues in foods, and the …

Targeted and non-targeted analysis of annonaceous alkaloids and acetogenins from Asimina and Annona species using UHPLC-QToF-MS

B Avula, JY Bae, T Majrashi, TY Wu, YH Wang… - … of pharmaceutical and …, 2018 - Elsevier
In current work, targeted and non-targeted analysis of alkaloids and acetogenins from
methanolic extracts of Asimina, Annona species and dietary supplements have been …

The Value of Caspase‐3 after the Application of Annona muricata Leaf Extract in COLO‐205 Colorectal Cancer Cell Line

M Abdullah, AF Syam, S Meilany… - Gastroenterology …, 2017 - Wiley Online Library
Annona muricata, commonly known as soursop, contains annonacin, acetogenin, and
polyphenol which are known to have chemopreventive effects on cancer. In this study, we …

Annonaceae acetogenins: A potential treatment for gynecological and breast cancer

DA Bravo-Alfaro, E Montalvo-González… - Fitoterapia, 2024 - Elsevier
Breast and gynecological cancers are major health concerns due to their increasing
incidence rates, and in some cases, their low survival probability. In recent years, multiple …

North American pawpaw (Asimina triloba L.) fruit: A critical review of bioactive compounds and their bioactivities.

B Adainoo - Trends in Food Science & Technology, 2024 - Elsevier
Abstract Background The North American pawpaw (Asimina triloba L.) fruit is an
underutilized specialty crop native to North America. Due to the short shelf life of the fruit, it …

The effect of an'Annona muricata'leaf extract on nutritional status and cytotoxicity in colorectal cancer: A randomized controlled trial

L Indrawati, P Ascobat, B Bela… - Asia Pacific journal …, 2017 - search.informit.org
Background and Objectives: Annona muricata leaf infusion has traditionally been consumed
to maintain health, but is now considered for use in treating cancer patients. The objective of …