Next generation gold drugs and probes: chemistry and biomedical applications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …
Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria
RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …
An update on recent developments in the prevention and treatment of Staphylococcus aureus biofilms
Staphylococcus aureus (S. aureus) readily forms biofilms on prosthetic devices such as the
pacemakers, heart valves, orthopaedic implants, and indwelling catheters. Its biofilms are …
pacemakers, heart valves, orthopaedic implants, and indwelling catheters. Its biofilms are …
Molecular mechanisms and clinical implications of the gold drug auranofin
S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics
Y Liu, Y Lu, Z Xu, X Ma, X Chen, W Liu - Drug Discovery Today, 2022 - Elsevier
Multidrug resistance (MDR) is a significant issue associated with the clinical application of
antibiotics. It is also challenging to discover and develop new antibiotics with novel …
antibiotics. It is also challenging to discover and develop new antibiotics with novel …
Niclosamide—A promising treatment for COVID‐19
Vaccines have reduced the transmission and severity of COVID‐19, but there remains a
paucity of efficacious treatment for drug‐resistant strains and more susceptible individuals …
paucity of efficacious treatment for drug‐resistant strains and more susceptible individuals …
Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and …
Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-
2, the causative agent of the COVID-19 pandemic. Though NIC is already FDA-approved …
2, the causative agent of the COVID-19 pandemic. Though NIC is already FDA-approved …
Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans
R Vazquez-Munoz, MJ Arellano-Jimenez… - BMC biomedical …, 2020 - Springer
Background Bismuth compounds are known for their activity against multiple
microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain …
microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain …
[HTML][HTML] Drug repurposing to fight colistin and carbapenem-resistant bacteria
L Peyclit, SA Baron, JM Rolain - Frontiers in Cellular and Infection …, 2019 - frontiersin.org
The emergence of new resistance mechanisms, the failure of classical antibiotics in clinic,
the decrease in the development of antibiotics in the industry are all challenges that lead us …
the decrease in the development of antibiotics in the industry are all challenges that lead us …
[HTML][HTML] Thioredoxin reductase is a valid target for antimicrobial therapeutic development against gram-positive bacteria
There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin
reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has …
reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has …