In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …

New approaches to stratify multiple myeloma patients based on prognosis and therapeutic
decision-making, or prediction, are needed since patients are currently managed in a similar …

Pancreatic ductal adenocarcinoma (PDAC) has prominent extracellular matrix (ECM) that
compromises treatments yet cannot be nonselectively disrupted without adverse …

Precursor states of multiple myeloma (MM) and its native tumor microenvironment need in-
depth molecular characterization to better stratify and treat patients at risk. Using single-cell …

Tumor progression and dissemination critically depend on support from the tumor
microenvironment, the ensemble of cellular and acellular components surrounding and …

Several haematological malignancies, including multiple myeloma (MM) and acute myeloid
leukaemia (AML), have well-defined precursor states that precede the development of overt …

The extracellular matrix (ECM) is a complex assembly of hundreds of proteins that
constitutes the scaffold of multicellular organisms. In addition to providing architectural and …

Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the
bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is …

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma
cell dyscrasia that consistently precedes multiple myeloma (MM) with a 1% risk of …

Multiple myeloma is rarely curable and its interactions with the bone marrow
microenvironment are evident. However, separating cause from effect remains a challenge …