Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which
leads to microangiopathy and macroangiopathy and ultimately increases the mortality of …

Diabetic nephropathy (DN) remains the leading cause of vascular morbidity and mortality in
diabetes patients. Despite the progress in understanding the diabetic disease process and …

Objective—Hyperglycemia is the main determinant of long-term diabetic complications,
mainly through induction of oxidative stress. NAD (P) H oxidase is a major source of glucose …

BACKGROUND AND PURPOSE The effects of metformin, an antidiabetic agent that
improves insulin sensitivity, on endothelial function have not been fully elucidated. This …

Psidium guajava Linn.(family Myrtaceae; PG) is a tropical fruit with a blood-glucose-lowering
effect in diabetic rats, but its mechanism of action is still unknown. We investigated the …

Cannabinoids have widespread effects on the cardiovascular system, only some of which
are mediated via G-protein-coupled cell surface receptors. The active ingredient of …

Objectives Hypertensive heart disease is a constellation of abnormalities that includes
cardiac fibrosis in response to elevated blood pressure, systolic and diastolic dysfunction …

Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, pioglitazone, is used
clinically to improve the glycemic state in patients with type-2 diabetes mellitus. Independent …

Effect of metformin treatment on blood pressure, endothelial function and oxidative stress in
streptozotocin (STZ)-induced diabetes in rats was studied. In vitro effect of metformin on …

Oxidative stress plays an important role in diabetic vascular dysfunction. The sources and
regulation of reactive oxygen species production in diabetic vasculature continue to be …