Nonviral cancer gene therapy: Delivery cascade and vector nanoproperty integration

Z Zhou, X Liu, D Zhu, Y Wang, Z Zhang, X Zhou… - Advanced drug delivery …, 2017 - Elsevier
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Recent advances in the development of gene delivery systems

YK Sung, SW Kim - Biomaterials research, 2019 - spj.science.org
Background Gene delivery systems are essentially necessary for the gene therapy of human
genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to …

Biodegradable synthetic polymers: Preparation, functionalization and biomedical application

H Tian, Z Tang, X Zhuang, X Chen, X Jing - Progress in Polymer Science, 2012 - Elsevier
Biodegradable polymers have been widely used and have greatly promoted the
development of biomedical fields because of their biocompatibility and biodegradability. The …

[PDF][PDF] Fusogenic reactive oxygen species triggered charge‐reversal vector for effective gene delivery

X Liu, J Xiang, D Zhu, L Jiang, Z Zhou, J Tang… - Advanced …, 2016 - researchgate.net
DOI: 10.1002/adma. 201504288 a reactive oxygen species (ROS)-labile charge-reversal
polymer, poly [(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide](B …

Nonviral vectors for gene delivery

MA Mintzer, EE Simanek - Chemical reviews, 2009 - ACS Publications
Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

Stimuli‐sensitive synthetic polypeptide‐based materials for drug and gene delivery

C He, X Zhuang, Z Tang, H Tian… - Advanced healthcare …, 2012 - Wiley Online Library
Stimuli‐sensitive synthetic polypeptides are unique biodegradable and biocompatible
synthetic polymers with structures mimicking natural proteins. These polymers exhibit …

Biodegradable polymers as non-viral carriers for plasmid DNA delivery

J Luten, CF van Nostrum, SC De Smedt… - Journal of Controlled …, 2008 - Elsevier
Gene therapy holds a great promise for the treatment of acquired and inherited diseases
with a genetic origin that are currently incurable. Non-viral gene delivery systems are …

Polymer systems for gene delivery—past, present, and future

SY Wong, JM Pelet, D Putnam - Progress in Polymer Science, 2007 - Elsevier
Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …

Polyethylene glycol-conjugated copolymers for plasmid DNA delivery

M Lee, SW Kim - Pharmaceutical research, 2005 - Springer
No Heading Polymeric gene delivery systems have been developed as an alternative for
viral gene delivery systems to overcome the problems in the use of viral gene carriers …

Stimuli-responsive peptide-based biomaterials as drug delivery systems

A Shah, MS Malik, GS Khan, E Nosheen… - Chemical Engineering …, 2018 - Elsevier
Stimuli-responsive proteins have gained a wide spread interest as functional biomaterials in
drug delivery area. However, particular attention has been diverted to peptide-based …