Angiotensin I-converting enzyme: genotype and disease associations

D Crisan, J Carr - The Journal of Molecular Diagnostics, 2000 - jmdjournal.org
Cardiovascular diseases (CVD) represent a paradigm for the complex interplay of
environmental risk factors and multiple genetic risk factors. Genetic abnormalities that are …

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

I Akhlaghipour, AR Bina, MR Mogharrabi, A Fanoodi… - Human Genomics, 2022 - Springer
Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and
organs, including eyes, kidneys, and cardiovascular system. According to the World Health …

Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 …

B Keavney, C McKenzie, S Parish, A Palmer, S Clark… - The lancet, 2000 - thelancet.com
Background The original report of a possible association between myocardial infarction and
the insertion/deletion (I/D) polymorphism of the gene for the angiotensin-1-converting …

Angiotensin II type 1 receptor A1166C gene polymorphism is associated with an increased response to angiotensin II in human arteries

PP van Geel, YM Pinto, AA Voors, H Buikema… - …, 2000 - Am Heart Assoc
An adenine/cytosine (A/C) base substitution at position 1166 in the angiotensin II type 1
receptor (AT1R) gene is associated with the incidence of essential hypertension and …

Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension

A Jones, SS Dhamrait, JR Payne, E Hawe, P Li… - …, 2003 - Am Heart Assoc
Renin-angiotensin systems may mediate cardiovascular disease pathogenesis through a
balance of actions of angiotensin II on (potentially proatherogenic) constitutive type 1 (AT1R) …

The p22 phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals

A Gardemann, P Mages, N Katz, H Tillmanns… - Atherosclerosis, 1999 - Elsevier
Background. Most recently, evidence has been presented that the NADH/NADPH oxidase
p22 phox C242T, but not the A640G gene polymorphism is associated with a reduced risk of …

The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high …

A Gardemann, H Weidemann, M Philipp… - European heart …, 1999 - academic.oup.com
Background There are conflicting results on the relationship of N5, N10-
methylenetetrahydrofolate reductase C677T gene variation in coronary artery disease and …

Effects of ACE I/D and AT1R-A1166C polymorphisms on blood pressure in a healthy normotensive primary care population: first results of the Hippocates study

LH Henskens, W Spiering, HE Stoffers… - Journal of …, 2003 - journals.lww.com
Background Several studies have assessed the relationship between the angiotensin-
converting enzyme (ACE) I/D or angiotensin II type 1 receptor (AT 1 R)-A 1166 C …

Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels

J Borzyszkowska, A Stanislawska-Sachadyn… - Journal of applied …, 2012 - Springer
This study examines whether renin-angiotensin-aldosterone system gene polymorphisms:
ACE (encoding for angiotensin converting enzyme) c. 2306-117_404 I/D, AGTR1 (encoding …

Angiotensin-converting enzyme gene polymorphism interacts with left ventricular ejection fraction and brain natriuretic peptide levels to predict mortality after …

BR Palmer, AP Pilbrow, TG Yandle… - Journal of the American …, 2003 - jacc.org
Objectives: The goal of this study was the exploration of the associations between the
angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and post …