Endogenous ligands of TLR2 and TLR4: agonists or assistants?
C Erridge - Journal of leukocyte biology, 2010 - academic.oup.com
Review summarizes the evidence supporting the existence of endogenous ligands of TLR2
and TLR4 and proposes that many may be better described as PAMP-sensitizing molecules …
and TLR4 and proposes that many may be better described as PAMP-sensitizing molecules …
Inflammation and immune surveillance in cancer
Chronic inflammation is a risk factor for tumor development. However, understanding the
effect of the immune system on tumor development has only been significantly advanced …
effect of the immune system on tumor development has only been significantly advanced …
Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-β1–dependent and–independent mechanisms
S Mi, Z Li, HZ Yang, H Liu, JP Wang, YG Ma… - The Journal of …, 2011 - journals.aai.org
Pulmonary fibrosis is the pathologic basis for a variety of incurable human chronic lung
diseases. IL-17A, a glycoprotein secreted from IL-17–producing cells, has recently been …
diseases. IL-17A, a glycoprotein secreted from IL-17–producing cells, has recently been …
STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation
H Tye, CL Kennedy, M Najdovska, L McLeod… - Cancer cell, 2012 - cell.com
Gastric cancer (GC) is associated with chronic inflammation; however, the molecular
mechanisms promoting tumorigenesis remain ill defined. Using a GC mouse model driven …
mechanisms promoting tumorigenesis remain ill defined. Using a GC mouse model driven …
Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain
P Mistry, MHW Laird, RS Schwarz… - Proceedings of the …, 2015 - National Acad Sciences
Toll-like receptor (TLR) signaling is initiated by dimerization of intracellular Toll/IL-1 receptor
resistance (TIR) domains. For all TLRs except TLR3, recruitment of the adapter, myeloid …
resistance (TIR) domains. For all TLRs except TLR3, recruitment of the adapter, myeloid …
Toll-like receptor 2 activation promotes tumor dendritic cell dysfunction by regulating IL-6 and IL-10 receptor signaling
M Tang, J Diao, H Gu, I Khatri, J Zhao, MS Cattral - Cell reports, 2015 - cell.com
Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of
cancer-associated inflammation that contributes to immune evasion, the mechanisms that …
cancer-associated inflammation that contributes to immune evasion, the mechanisms that …
DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial–mesenchymal transition in human breast cancer
Epithelial-to-mesenchymal transition (EMT), a crucial developmental program, contributes to
cancer invasion and metastasis. In this study, we show that death-effector domain …
cancer invasion and metastasis. In this study, we show that death-effector domain …
The HSP immune network in cancer
Z Albakova, Y Mangasarova - Frontiers in immunology, 2021 - frontiersin.org
Heat shock proteins are molecular chaperones which support tumor development by
regulating various cellular processes including unfolded protein response, mitochondrial …
regulating various cellular processes including unfolded protein response, mitochondrial …
[HTML][HTML] Discovery of small molecule inhibitors of the TLR1-TLR2 complex
The protein complex of toll-like receptor 1 and 2 (TLR1/2) is an important regulator of innate
immunity, and therefore provides an attractive target for the treatment of various immune …
immunity, and therefore provides an attractive target for the treatment of various immune …
Toll-like receptor 2 at the crossroad between cancer cells, the immune system, and the microbiota
Toll-like receptor 2 (TLR2) expressed on myeloid cells mediates the recognition of harmful
molecules belonging to invading pathogens or host damaged tissues, leading to …
molecules belonging to invading pathogens or host damaged tissues, leading to …