Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Proteases, including intracellular proteases, play roles at many different stages of malignant
progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of …

Introduction: Cathepsin B is of significant importance to cancer therapy as it is involved in
various pathologies and oncogenic processes in humans. Numerous studies have shown …

The importance of epigenetic modifications such as DNA methylation in tumorigenesis is
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Communication between the cell and its surrounding environment, consisting of
proteinaceous (non-living material) and extracellular matrix (ECM), is important for …

Background Recently, the distinction between left-and right-sided colon cancer (LCC and
RCC) has been brought into focus. RCC is associated with an inferior overall survival and …

The epithelial to mesenchymal transition (EMT) program is a crucial component in the
processes of morphogenesis and embryonic development. The transition of epithelial to …

Tumor microenvironment, including extracellular matrix (ECM) and stromal cells, is a key
player during tumor development, from initiation, growth and progression to metastasis …

Transforming growth factor-β (TGF-β) is a pleiotropic growth factor with broad tissue
distribution that plays critical roles during embryonic development, normal tissue …