Antimicrobial peptides as anticancer agents: functional properties and biological activities

AL Tornesello, A Borrelli, L Buonaguro, FM Buonaguro… - Molecules, 2020 - mdpi.com
Antimicrobial peptides (AMPs), or host defense peptides, are small cationic or amphipathic
molecules produced by prokaryotic and eukaryotic organisms that play a key role in the …

Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Human antimicrobial peptides and proteins

G Wang - Pharmaceuticals, 2014 - mdpi.com
As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Cathelicidins modulate TLR-activation and inflammation

MR Scheenstra, RM Van Harten… - Frontiers in …, 2020 - frontiersin.org
Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …

Design of antimicrobial peptides: progress made with human cathelicidin LL-37

G Wang, JL Narayana, B Mishra, Y Zhang… - … Peptides: Basics for …, 2019 - Springer
The incorporation of the innate immune system into humans is essential for survival and
health due to the rapid replication of invading microbes and the delayed action of the …

Clinical applications of antimicrobial peptides (AMPs): where do we stand now?

M Divyashree, MK Mani, D Reddy… - Protein and peptide …, 2020 - ingentaconnect.com
In this era of multi-drug resistance (MDR), antimicrobial peptides (AMPs) are one of the most
promising classes of potential drug candidates to combat communicable as well as …

The human cathelicidin antimicrobial peptide LL-37 and mimics are potential anticancer drugs

K Kuroda, K Okumura, H Isogai, E Isogai - Frontiers in oncology, 2015 - frontiersin.org
Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial
pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge …

Glioblastoma hijacks microglial gene expression to support tumor growth

SLN Maas, ER Abels, LL Van De Haar, X Zhang… - Journal of …, 2020 - Springer
Background Glioblastomas are the most common and lethal primary brain tumors. Microglia,
the resident immune cells of the brain, survey their environment and respond to pathogens …

LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity

A Fabisiak, N Murawska, J Fichna - Pharmacological Reports, 2016 - Elsevier
Antimicrobial peptides (AMPs) is a large family of compounds serving as natural antibiotics,
widely distributed across the organism, mainly in mucus layers. They are designed to …

Regulation of inflammation by members of the formyl-peptide receptor family

K Chen, Z Bao, W Gong, P Tang, T Yoshimura… - Journal of …, 2017 - Elsevier
Inflammation is associated with a variety of diseases. The hallmark of inflammation is
leukocyte infiltration at disease sites in response to pathogen-or damage-associated …