Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Due to the negative impact of reactive species (including free radicals) on humans and
animals, the investigations to find effective substances (antioxidants), which protect living …

Background Epidemiological studies has revealed that a diet rich in fruits and vegetables
could lower the risk of certain cancers. In this setting, natural polyphenols are potent …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …

The cure rate of osteosarcoma has not improved in the past 30 years. The search for new
treatments and drugs is urgently needed. Apatinib is a high selectivity inhibitor of vascular …

Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Quercetin, as a member of flavonoids, has emerged as a potential therapeutic agent in
cardiovascular diseases (CVDs) in recent decades. In this comprehensive literature review …