Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

The concept of targeting cholesterol metabolism to treat cancer has been widely tested in
clinics, but the benefits are modest, calling for a complete understanding of cholesterol …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling
and the catabolic turnover of macromolecules. How these janus-faced activities are …

Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …

Transcription factor EB (TFEB) is a basic helix–loop–helix leucine zipper transcription factor
that acts as a master regulator of lysosomal biogenesis, lysosomal exocytosis, and macro …

T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …

Phagocytosis is a fundamental immunobiological process responsible for the removal of
harmful particulates. While the number of phagocytic events achieved by a single phagocyte …

Macrophages are critical to turn noninflamed" cold tumors" into inflamed" hot tumors".
Emerging evidence indicates abnormal cholesterol metabolites in the tumor …