Kidney-Specific Interleukin-17 Responses During Infection and Injury

D Peroumal, PS Biswas - Annual Review of Immunology, 2023 - annualreviews.org
The kidneys are life-sustaining organs that are vital to removing waste from our body.
Because of their anatomic position and high blood flow, the kidneys are vulnerable to …

The critical role of dysregulated autophagy in the progression of diabetic kidney disease

Z Zhang, Y Sun, J Xue, D Jin, X Li, D Zhao… - Frontiers in …, 2022 - frontiersin.org
Diabetic kidney disease (DKD) is one of the major public health problems in society today. It
is a renal complication caused by diabetes mellitus with predominantly microangiopathy and …

Effects of modified Huangqi Chifeng decoction on the IL-17 signaling pathway in an IgA nephropathy rat model

S Ma, B Yang, M Zhao, P Li, J Fan, M Chang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Immunoglobulin A nephropathy (IgAN) is an immune-
related primary glomerular disease prevalent worldwide, with complicated clinical …

Autophagy in renal fibrosis: Protection or promotion?

R Dai, L Zhang, H Jin, D Wang, M Cheng… - Frontiers in …, 2022 - frontiersin.org
Autophagy is a process that degrades endogenous cellular protein aggregates and
damaged organelles via the lysosomal pathway to maintain cellular homeostasis and …

Screening and identification of hub genes in the development of early diabetic kidney disease based on weighted gene co-expression network analysis

R Wei, J Qiao, D Cui, Q Pan, L Guo - Frontiers in Endocrinology, 2022 - frontiersin.org
Objective The study aimed to screen key genes in early diabetic kidney disease (DKD) and
predict their biological functions and signaling pathways using bioinformatics analysis of …

Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling

R Deguchi, T Komori, S Yamashita, T Hisaoka… - Scientific Reports, 2024 - nature.com
Oncostatin M (OSM) has pleiotropic effects on various inflammatory diseases, including
kidney stone disease. The prevalence of kidney stones has increased worldwide, despite …

IL-17 in type II diabetes mellitus (T2DM) immunopathogenesis and complications; molecular approaches

R Elahi, M Nazari, V Mohammadi, K Esmaeilzadeh… - Molecular …, 2024 - Elsevier
Chronic inflammation has long been considered the characteristic feature of type II diabetes
mellitus (T2DM) Immunopathogenesis. Pro-inflammatory cytokines are considered the …

Shen-yan-yi-hao oral solution ameliorates IgA nephropathy via intestinal IL-17/NF-κB pathway

H Song, GQ Liang, MS Yu, Y Shan, J Shi… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Immunoglobulin A nephropathy (IgAN) is the most
common primary glomerulonephritis in the world, it is one of the most common causes of …

Circulating IL-17 reduces the risk of cisplatin-induced hearing loss in children: a bidirectional two-sample Mendelian randomization study

Y Xu, C Huang, J Liu, Y Xu, H Yang - Scientific Reports, 2023 - nature.com
Studies have reported that cytokines and their related signaling pathways play a role in
inner ear diseases. In clinical practice, approximately 50% of pediatric cancer patients …

[HTML][HTML] Silencing long noncoding RNA-CES1P1 suppresses glomerular endothelial cell inflammation in diabetic nephropathy

X Zhang, L Ren, J Wei, Y Ni, L Sun, X Zhao… - International …, 2022 - Elsevier
Diabetic nephropathy (DN) has become the main cause of end-stage renal disease
worldwide. Inflammation is associated with the occurrence and development of DN, and …