Chiral amino acids are extensively applied in the pharmaceutical, food, cosmetic,
agricultural, and feedstuff industries. The development of synthetic methodologies for …

Recent developments of stereoselective biocatalytic and chemocatalytic methods are
discussed. The review provides a guide to the use of biocatalytic methods in the area of …

Reductive amination is one of the most important methods for the synthesis of chiral amines.
Here we report the discovery of an NADP (H)-dependent reductive aminase from Aspergillus …

Biocatalysis has been increasingly used for pharmaceutical synthesis in an effort to make
manufacturing processes greener and more sustainable. Biocatalysts that possess excellent …

Highlights•Imine reductases (IREDs) enable the asymmetric synthesis of amines from
imines.•The development of annotated sequence databases has led to the discovery of new …

Introduction of innovative biocatalytic processes offers great promise for applications in
green chemistry. However, owing to limited catalytic performance, the enzymes harvested …

Ammonia-lyases and aminomutases are mechanistically and structurally diverse enzymes
which catalyze the deamination and/or isomerization of amino acids in nature by cleaving or …

Although C–N bonds are ubiquitous in natural products, pharmaceuticals and
agrochemicals, biocatalysts forging these bonds with high atom-efficiency and …

Amines constitute the major targets for the production of a plethora of chemical compounds
that have applications in the pharmaceutical, agrochemical and bulk chemical industries …

Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …