Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Smooth muscle cells (SMCs) execute important physiological functions in numerous vital
organ systems, including the vascular, gastrointestinal, respiratory, and urogenital tracts …

Acute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation
(OxPhos) for survival, and they continually adapt to fluctuations in nutrient and oxygen …

Although right ventricular (RV) function is the primary determinant of morbidity and mortality
in pulmonary arterial hypertension (PAH), the molecular mechanisms of RV remodeling and …

Cardiomyopathies (CMPs) represent a significant healthcare burden and are a major cause
of heart failure leading to premature death. Several CMPs are now recognized to have a …

The mechanisms occurring during sepsis that produce an increased risk of cardiovascular
(CV) disease (CVD) are poorly understood. Even less information exists regarding CV …

Enhanced proliferation and migration of vascular smooth muscle cells (VSMCs) contributes
to vascular remodeling in hypertension. Adventitial fibroblasts (AFs)-derived extracellular …

For electromechanical coupling of cardiomyocytes, intercalated discs (ICDs) are pivotal as
highly specialized intercellular contact areas. ICD consists of adhesive contacts, such as …

Modifier genes contribute significantly to our understanding of pathophysiology in human
diseases; however, effective approaches to identify modifier genes are still lacking. Here, we …