In the context of the structural complexity necessary for a molecule to selectively display a
therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
loss of cognitive functions. While the exact causes of this debilitating disorder remain …

The high reactivity of gold-vinylidene complexes, generated in situ by [1, 2]-bromine shift
from the corresponding 1-bromoalkynes, allows the activation of one of the strongest bonds …

Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and
previous studies showed that regulation of I2R signaling has neuroprotective potential. In …

The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind
due to their vast prevalence and the lack of efficacious treatments. In this scenario, we …

Abstract Imidazoline‐2 binding sites (I2BS) exhibit specific expression in reactive astrocytes
of the brain and are implicated in various pathophysiological processes, including …

Humanity is facing a vast prevalence of neurodegenerative diseases, with Alzheimer's
disease (AD) being the most dominant, without efficacious drugs, and with only a few …

Agmatine is an endogenous biogenic amine that exerts various effects on the central
nervous system. The hypothalamic preoptic area (POA, thermoregulatory command center) …

Recent studies pointed out the modulation of imidazoline I 2 receptors (I 2-IR) by selective
ligands as a putative strategy to face neurodegenerative diseases. Foregoing the classical 2 …

In searching for novel targets to design antidepressants, among the characterized
imidazoline receptors (IR), I2 receptors are an innovative therapeutical approach since they …