Transfusion of older stored blood and risk of death: a meta‐analysis

D Wang, J Sun, SB Solomon, HG Klein… - Transfusion, 2012 - Wiley Online Library
BACKGROUND: Blood for transfusion is stored for up to 42 days. Older blood develops
lesions and accumulates potentially injurious substances. Some studies report increasing …

“Blood failure” time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation

CK Bjerkvig, G Strandenes, HS Eliassen… - …, 2016 - Wiley Online Library
Hemorrhagic shock is both a local and systemic disorder. In the context of systemic effects,
blood loss may lead to levels of reduced oxygen delivery (DO2) sufficient to cause tissue …

Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial

DA Fergusson, P Hébert, DL Hogan, L LeBel… - Jama, 2012 - jamanetwork.com
Context Even though red blood cells (RBCs) are lifesaving in neonatal intensive care,
transfusing older RBCs may result in higher rates of organ dysfunction, nosocomial infection …

The Age of Blood Evaluation (ABLE) randomized controlled trial: study design

J Lacroix, P Hébert, D Fergusson, A Tinmouth… - Transfusion medicine …, 2011 - Elsevier
Red blood cells (RBCs) are transfused to treat anemia and to maintain oxygen delivery to
vital organs during critical illness. Laboratory and observational studies have raised the …

Red blood cell transfusions are independently associated with intra-hospital mortality in very low birth weight preterm infants

AMN dos Santos, R Guinsburg, MFB de Almeida… - The Journal of …, 2011 - Elsevier
OBJECTIVE: To test the hypothesis that red blood cell (RBC) transfusions in preterm infants
are associated with increased intra-hospital mortality. STUDY DESIGN: Variables …

Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants?

CD Josephson, A Wesolowski, G Bao… - The Journal of …, 2010 - Elsevier
OBJECTIVE: To test the hypothesis that red blood cell (RBC) transfusions increase the risk
of necrotizing enterocolitis (NEC) in premature infants, we investigated whether the risk of …

Anemia, red blood cell transfusions, and necrotizing enterocolitis

A Maheshwari, RM Patel, RD Christensen - Seminars in pediatric surgery, 2018 - Elsevier
In the past 15 years, multiple clinical studies have identified a temporal association between
red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC). With some variability …

Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS)(Section 7)

ME Steiner, SF Assmann, JH Levy, J Marshall… - … and Apheresis Science, 2010 - Elsevier
The question of whether storage of red blood cells (RBCs) alters their capacity to deliver
oxygen and affects patient outcomes remains in a state of clinical equipoise. Studies of the …

Stored red blood cell transfusions: Iron, inflammation, immunity, and infection

EA Hod, SL Spitalnik - Transfusion clinique et biologique, 2012 - Elsevier
The potential adverse effects of transfusion of red blood cells after prolonged storage have
been hotly debated. During refrigerated storage, red blood cells are damaged, a process …

Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients

F Gauvin, PC Spinella, J Lacroix, G Choker… - …, 2010 - Wiley Online Library
BACKGROUND: The objective was to determine if there is an association between red
blood cell (RBC) storage time and development of new or progressive multiple organ …