Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Epigenetic mechanisms play critical roles in oogenesis and early embryo development in
mammals. One of these epigenetic mechanisms, DNA methylation is accomplished through …

Effective cryopreservation protocols are essential for long-term storage of cells and their
subsequent clinical application. Freezing protocols are generally considered as safe; …

Children conceived by assisted reproductive technologies (ART) have a moderate risk for a
number of adverse events and conditions. The question whether this additional risk is …

Cryopreservation techniques for mammalian oocytes and embryos have rapidly progressed
during the past two decades, emphasizing their importance in various assisted reproductive …

Understanding the molecular level changes of oocyte cryopreservation and the subsequent
warming process is essential for improving the oocyte cryopreservation technologies. Here …

Extracellular matrix (ECM) stiffness has profound effects on the regulation of cell functions.
DNA methylation is an important epigenetic modification governing gene expression …

It is well established that there is a heritable element of susceptibility to chronic human
ailments, yet there is compelling evidence that some components of such heritability are …

Abstract The vitrification of Germinal Vesicle (immature) oocytes is beneficial for
preservation of fertility in cases involving reproductive problems. The use of nanoparticles …

Aim: The study aimed to assess the effect of in vitro vitrification and maturation on the
nuclear configuration, cytoplasmic maturation and global DNA methylation pattern of human …