Since the initial clinical approval in the late 1990s and remarkable anticancer effects for
certain types of cancer, molecular targeted therapy utilizing small molecule agents or …

Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on
the surface of the brain. Historically considered a result of head trauma, recent evidence …

Blood vessels and lymphatic vessels form extensive networks that are essential for the
transport of fluids, gases, macromolecules and cells within the large and complex bodies of …

Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that
monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs])(1) are a …

Pericytes are branched cells embedded within the basement membrane of capillaries and
post-capillary venules. They provide an incomplete investment to endothelial cells, thus …

The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall …

Abstract The angiopoietins Ang-1 and Ang-2 have been identified as ligands with opposing
functions of the receptor tyrosine kinase Tie-2 regulating endothelial cell survival and …

Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …

Stroke causes cell death but also birth and migration of new neurons within sites of ischemic
damage. The cellular environment that induces neuronal regeneration and migration after …

Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment
is a key event in cancer development and progression. In the last decade, emerging …