MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression.
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …

MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …

Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among the currently
identified> 1,500 human RNA-binding proteins (RBPs), there are only a handful of RBPs …

Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome
changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small …

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Heterozygous
loss-of-function point mutations of miRNA genes are associated with several human …

The total number of protein-coding genes in the human genome is not significantly higher
than those in much simpler eukaryotes, despite a general increase in genome size …

Triple-negative breast cancer (TNBC) is typically associated with poor prognosis due to its
only partial response to chemotherapy and lack of clinically established targeted therapies …

Gene regulation by microRNAs (miRNAs) plays important roles in development, physiology,
and disease. miRNAs are an abundant class of noncoding RNAs that are generated through …

RNA-binding proteins (RBPs) play crucial roles in almost all aspects of cellular biology. RBP
binding at specific target sites impacts expression of functionally coordinated sets of mRNAs …

Background Combinatorial gene regulation by multiple microRNAs (miRNAs) is widespread
and closely spaced target sites often act cooperatively to achieve stronger repression …