Background: At the end of the last century, genome-wide association studies revealed a
significant genetic association between bipolar disorder and autoimmune diseases …

Pathway analysis, also known as gene-set enrichment analysis, is a multilocus analytic
strategy that integrates a priori, biological knowledge into the statistical analysis of high …

Objective Metabolic syndrome is a health-threatening condition suffered by approximately
one third of schizophrenia patients and largely attributed to antipsychotic medication …

Objective: The authors investigated the distributions and trajectories of physical illnesses
preceding the diagnosis of bipolar disorder with comparison to schizophrenia and general …

Objectives Metabolically based distinctions for disturbances in glucose and insulin may
provide meaningful insights both clinically and mechanistically. Methods Data were derived …

Genome-wide association studies (GWAS) of mood disorders in large case-control cohorts
have identified numerous risk loci, yet pathophysiological mechanisms remain elusive …

Introduction Bipolar disorder (BD) is characterized by recurrent episodes of depression and
mania and affects up to 2% of the population worldwide. Patients suffering from bipolar …

In this work we develop a novel algorithm for reconstructing the genomes of ancestral
individuals, given genotype or sequence data from contemporary individuals and an …

Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD
genetic characteristics can help with early prevention and individualized treatment. At the …

Objective Genetic factors underpin the narrow intraindividual variability of thyroid function,
although precise contributions of environmental vs genetic factors remain uncertain. We …