Metabolic theory of preeclampsia: Implications for maternal cardiovascular health

MM Manoharan, GC Montes… - American Journal …, 2024 - journals.physiology.org
Preeclampsia (PE) is a multisystemic disorder of pregnancy that not only causes perinatal
mortality and morbidity but also has a long-term toll on the maternal and fetal cardiovascular …

10. Role of high dimensional technology in preeclampsia (omics in preeclampsia)

L Youssef, L Testa, F Crovetto, F Crispi - Best Practice & Research Clinical …, 2024 - Elsevier
Preeclampsia is a pregnancy-specific disease that has no known precise cause. Integrative
biology approach based on multi-omics has been applied to identify upstream pathways and …

Proteomics and metabolomics profiling of platelets and plasma mediators of thrombo-inflammation in gestational hypertension and preeclampsia

LGN de Almeida, D Young, L Chow, J Nicholas, A Lee… - Cells, 2022 - mdpi.com
Platelets may be pivotal mediators of the thrombotic and coagulopathic complications of
preeclampsia (PE), linking inflammation and thrombosis with endothelial and vascular …

Growth-Restricted Fetuses and Offspring Reveal Adverse Sex-Specific Metabolic Responses in Preeclamptic Mice Expressing Human sFLT1

R Vogtmann, M Bao, MV Dewan, A Riedel… - International Journal of …, 2023 - mdpi.com
Fetal adaptations to harmful intrauterine environments due to pregnancy disorders such as
preeclampsia (PE) can negatively program the offspring's metabolism, resulting in long-term …

Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia

L Tan, Z Ouyang, Z Chen, F Sun, H Guo… - Lipids in Health and …, 2023 - Springer
Background The adipokine chemerin regulates adipogenesis and the metabolic function of
both adipocytes and liver. Chemerin is elevated in preeclamptic women, and …

Predicting the onset of preeclampsia by longitudinal monitoring of metabolic changes throughout pregnancy with Raman spectroscopy

S Ghazvini, S Uthaman, L Synan, EC Lin… - Bioengineering & …, 2024 - Wiley Online Library
Preeclampsia is a life‐threatening pregnancy disorder. Current clinical assays cannot
predict the onset of preeclampsia until the late 2nd trimester, which often leads to poor …

First-trimester preterm preeclampsia prediction with metabolite biomarkers: differential prediction according to maternal body mass index

R Tuytten, A Syngelaki, G Thomas, A Panigassi… - American Journal of …, 2023 - Elsevier
Background Prediction of preeclampsia risk is key to informing effective maternal care.
Current screening for preeclampsia at 11 to 13 weeks of gestation using maternal …

Comprehensive microarray analysis of severe preeclampsia placenta to identify differentially expressed genes, biological pathways, hub genes, and their related non …

M Shabani, M Eghbali, A Abiri, M Abiri - Placenta, 2024 - Elsevier
Introduction Preeclampsia (PE) is a serious pregnancy-related complication caused by high
blood pressure in pregnant women. The severe form has more devastating effects …

Metabolic dynamics and prediction of sFGR and adverse fetal outcomes: a prospective longitudinal cohort study

N Huang, W Chen, H Jiang, J Yang, Y Zhang, H Shi… - BMC medicine, 2023 - Springer
Background Selective fetal growth restriction (sFGR) is an extreme complication that
significantly increases the risk of perinatal mortality and long-term adverse neurological …

Plasma metabolic profile reveals signatures of maternal health during gestational hypertension and preeclampsia without and with severe features

JNS Kaihara, FR de Moraes, PR Nunes, MG Alves… - PloS one, 2024 - journals.plos.org
Preeclampsia, a pregnancy-specific syndrome, poses substantial risks to maternal and
neonatal health, particularly in cases with severe features. Our study focuses on evaluating …