The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

Functional hypothalamic amenorrhea (FHA) is the most common cause of secondary
amenorrhea in women of reproductive age. FHA is predominantly caused by stress …

Present therapeutic approaches do not effectively target metastatic cancers, often limited by
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …

Background There is limited comprehensive evidence on the potential association between
early menarche and subsequent health outcomes. Aim To evaluate the existing evidence for …

Carbamates are widely used and known around the world as pesticides in spite of also
having medical applications. This class of chemicals is classified as acetylcholinesterase …

The intestinal microbiota and its derived short-chain fatty acids (SCFAs) can reverse obesity
and obesity-related metabolic diseases, but whether it has an effect on obesity complicated …

Peptide hormones play a prominent role in controlling energy homeostasis and metabolism.
They have been implicated in controlling appetite, the function of the gastrointestinal and …

The male reproductive system consists of the internal structures: the testes, epididymis, vas
deferens, prostate, and the external structures: the scrotum and penis. These structures are …

Puberty is a developmental period characterized by a broad range of physiologic changes
necessary for the acquisition of adult sexual and reproductive maturity. These changes …

Kisspeptin signaling through its G protein-coupled receptor, KISS1R, plays an indispensable
role in regulating reproduction via the hypothalamic-pituitary-gonadal axis. Dysregulation of …