In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons

N Angliker, MA Rüegg - Bioarchitecture, 2013 - Taylor & Francis
The mammalian target of rapamycin (mTOR) assembles into two distinct multi-protein
complexes called mTORC1 and mTORC2. While mTORC1 controls the signaling pathways …

Genotype–phenotype correlation in interstitial 6q deletions: a report of 12 new cases

JA Rosenfeld, D Amrom, E Andermann, F Andermann… - Neurogenetics, 2012 - Springer
Interstitial deletions of 6q are associated with variable phenotypes, including growth
retardation, dysmorphic features, upper limb malformations, and Prader–Willi (PW)-like …

Effects of early versus late rehabilitative training on manual dexterity after corticospinal tract lesion in macaque monkeys

Y Sugiyama, N Higo, K Yoshino-Saito… - Journal of …, 2013 - journals.physiology.org
Dexterous hand movements can be restored with motor rehabilitative training after a lesion
of the lateral corticospinal tract (l-CST) in macaque monkeys. To maximize effectiveness, the …

Increased expression of the growth‐associated protein 43 gene in the sensorimotor cortex of the macaque monkey after lesioning the lateral corticospinal tract

N Higo, Y Nishimura, Y Murata, T Oishi… - Journal of …, 2009 - Wiley Online Library
To investigate the neural basis for functional recovery of the cerebral cortex following spinal
cord injury, we measured the expression of growth‐associated protein 43 (GAP‐43), which …

Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia

RD Paz, NC Andreasen, SZ Daoud… - American Journal of …, 2006 - Am Psychiatric Assoc
Objective: The purpose of this study was to evaluate the functional state of glutamatergic
neurons in the cerebellar cortex of patients with schizophrenia. Method: The authors …

[HTML][HTML] Development and characterization of a macaque model of focal internal capsular infarcts

Y Murata, N Higo - Plos one, 2016 - journals.plos.org
Several studies have used macaque monkeys with lesions induced in the primary motor
cortex (M1) to investigate the recovery of motor function after brain damage. However, in …

Cell type-and region-specific expression of neurogranin mRNA in the cerebral cortex of the macaque monkey

N Higo, T Oishi, A Yamashita, K Matsuda… - Cerebral …, 2004 - academic.oup.com
Neurogranin is a postsynaptic substrate for protein kinase C (PKC). It has been identified in
the central nervous system, and the expression has been related to postsynaptic plasticity …

[HTML][HTML] c-Fos expression during temporal order judgment in mice

M Wada, N Higo, S Moizumi, S Kitazawa - PLoS One, 2010 - journals.plos.org
The neuronal mechanisms for ordering sensory signals in time still need to be clarified
despite a long history of research. To address this issue, we recently developed a …

[HTML][HTML] Modelos fisiopatológicos de la esquizofrenia; de dopamina a glutamato, de glutamato a GABA

H Paz - Revista chilena de neuro-psiquiatría, 2005 - SciELO Chile
A pesar de los avances en el conocimiento de las bases biológicas de la conducta, los
mecanismos neurobiológicos precisos involucrados en la esquizofrenia permanecen …

Time-and area-dependent macrophage/microglial responses after focal infarction of the macaque internal capsule

J Kato, Y Murata, I Takashima, N Higo - Neuroscience Research, 2021 - Elsevier
We quantitatively investigated temporal changes of macrophages and microglia (MΦ/MG)
after focal infarction of the internal capsule using a macaque model we recently established …