The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …

Cancer is a complex disease involving alterations of multiple processes, with both genetic
and epigenetic features contributing as core factors to the disease. In recent years, it has …

MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene
expression through post-transcriptional regulation of messenger RNA. Compelling evidence …

miRNAs are some of the most well-characterized regulators of gene expression. Integral to
several physiological processes, their aberrant expression often drives the pathogenesis of …

Abstract microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which
structurally consist of 19–22 nucleotides in length and functionally act as one of the main …

Prostate cancer (PC) is a very important kind of male malignancies. When PC evolves into a
stage of hormone resistance or metastasis, the fatality rate is very high. Currently …

Clear cell renal cell carcinoma (ccRCC) is the third most common urological cancer, and it
has the highest mortality rate. The increasing drug resistance of metastatic ccRCC has …

Changes in DNA methylation have been causally linked with cancer and provide promising
biomarkers for detection in biological fluids such as blood, urine, and saliva. The field has …

Background The rising incidence of renal cell carcinomas (RCC) constitutes a significant
challenge owing to risk of overtreatment. Because aberrant microRNA (miR) promoter …

Abstract Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is responsible for
metabolism of an endogenous inhibitor of nitric oxide synthase (NOS), asymmetric …