[HTML][HTML] Tick immune system: what is known, the interconnections, the gaps, and the challenges

AC Fogaça, G Sousa, DB Pavanelo, E Esteves… - Frontiers in …, 2021 - frontiersin.org
Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

[HTML][HTML] The dual regulation of apoptosis by flavivirus

Y Pan, A Cheng, M Wang, Z Yin, R Jia - Frontiers in microbiology, 2021 - frontiersin.org
Apoptosis is a form of programmed cell death, which maintains cellular homeostasis by
eliminating pathogen-infected cells. It contains three signaling pathways: death receptor …

[HTML][HTML] A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses

AA Amarilla, JDJ Sng, R Parry, JM Deerain… - Nature …, 2021 - nature.com
The current COVID-19 pandemic is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the viral RNA …

[HTML][HTML] An optimized high-throughput immuno-plaque assay for SARS-CoV-2

AA Amarilla, N Modhiran, YX Setoh… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been identified as the
causative agent of coronavirus disease 2019 and is capable of human-to-human …

[HTML][HTML] Flaviviruses: innate immunity, inflammasome activation, inflammatory cell death, and cytokines

Y Pan, W Cai, A Cheng, M Wang, Z Yin… - Frontiers in …, 2022 - frontiersin.org
The innate immune system is the host's first line of defense against the invasion of
pathogens including flavivirus. The programmed cell death controlled by genes plays an …

[HTML][HTML] Uncovering the Worldwide Diversity and Evolution of the Virome of the Mosquitoes Aedes aegypti and Aedes albopictus

R Parry, ME James, S Asgari - Microorganisms, 2021 - mdpi.com
Aedes aegypti, the yellow fever mosquito, and Aedes albopictus, the Asian tiger mosquito,
are the most significant vectors of dengue, Zika, and Chikungunya viruses globally. Studies …

[HTML][HTML] Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1

X Chen, Y Wang, Z Xu, ML Cheng, QQ Ma… - Nature …, 2023 - nature.com
Human RNA binding protein Musashi-1 (MSI1) plays a critical role in neural progenitor cells
(NPCs) by binding to various host RNA transcripts. The canonical MSI1 binding site (MBS) …

Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA

RA Jones, AL Steckelberg, Q Vicens, MJ Szucs… - Rna, 2021 - rnajournal.cshlp.org
During infection by a flavivirus (FV), cells accumulate noncoding subgenomic flavivirus
RNAs (sfRNAs) that interfere with several antiviral pathways. These sfRNAs are formed by …

[HTML][HTML] Structural analysis of 3'UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution

A Slonchak, R Parry, B Pullinger, JDJ Sng… - Nature …, 2022 - nature.com
Subgenomic flaviviral RNAs (sfRNAs) are virus-derived noncoding RNAs produced by
pathogenic mosquito-borne flaviviruses (MBF) to counteract the host antiviral response. To …

[HTML][HTML] Apoptosis during ZIKA virus infection: too soon or too late?

J Turpin, D El Safadi, G Lebeau, M Krejbich… - International Journal of …, 2022 - mdpi.com
Cell death by apoptosis is a major cellular response in the control of tissue homeostasis and
as a defense mechanism in the case of cellular aggression such as an infection. Cell self …