Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Skin is the largest organ of the body with important protective functions, which become
compromised with time due to both intrinsic and extrinsic ageing processes. Cellular …

An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An
unbiased whole-genome methylome was studied in the wound-edge tissue of patients with …

The accumulation of senescent cells (SnCs) is a causal factor of various age‐related
diseases as well as some of the side effects of chemotherapy. Pharmacological elimination …

Senescent cells (SCs) accumulate with age and cause various age-related diseases.
Clearance of SCs by transgenic or pharmaceutical strategies has been demonstrated to …

Cellular senescence is now recognized as one of the nine hallmarks of ageing. Recent data
show the involvement of senescent cells in tissue ageing and some age-related diseases …

The tumor suppressor p53 is a key regulator of apoptosis induced by various cellular
stresses. p53 can induce apoptosis by two mechanisms. First, p53 acts as a transcription …

Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and
oncogenic stress. Long-term retention of senescent cells in the body, which is attributed to …

Senescence is a cell state occurring in vitro and in vivo after successive replication cycles
and/or upon exposition to various stressors. It is characterized by a strong cell cycle arrest …

Background: Cancer, an uncontrolled multistage disease causing swift division of cells, is a
leading disease with the highest mortality rate. Cellular heterogeneity, evading growth …