Abstract Treatment protocols for breast cancer depend predominantly on receptor status with
respect to estrogen (estrogen receptor alpha), progesterone (progesterone receptor) and …

The role of androgen receptor (AR) activation and expression is well understood in prostate
cancer. In breast cancer, expression and activation of AR is increasingly recognized for its …

Purpose: Preclinical data demonstrating androgen receptor (AR)–positive (AR+) triple-
negative breast cancer (TNBC) cells are sensitive to AR antagonists, and PI3K inhibition …

The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the
lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …

Molecularly targeted therapies for advanced prostate cancer include castration modalities
that suppress ligand-dependent transcriptional activity of the androgen receptor (AR) …

Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …

Background The intractability of castration-resistant prostate cancer (CRPC) is exacerbated
by tumour heterogeneity, including diverse alterations to the androgen receptor (AR) axis …

Alteration to the expression and activity of androgen receptor (AR) coregulators in prostate
cancer is an important mechanism driving disease progression and therapy resistance …

The endometrium is a complex multicellular tissue that is exquisitely sensitive to the actions
of sex steroids synthesised in the ovary (endocrine system). Recent studies have highlighted …

The androgen receptor (AR) is a ligand-dependent transcription factor, and its effects on
breast range from physiological pubertal development and age-related modifications to …