Ovarian cancer is the deadliest gynecological cancer, leading to over 152,000 deaths each
year. A late diagnosis is the primary factor causing a poor prognosis of ovarian cancer and …

The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …

The biological compositions including cells, proteins/peptides, nucleic acids, extracellular
vesicles (EVs) and metabolites are no doubt closely related to almost all physiological and …

The rationale for early detection of ovarian cancer is compelling. Ovarian cancer confined to
the ovaries (stage I) can be cured in up to 90% of patients, and disease confined to the …

Early detection of ovarian cancer remains an important unmet medical need. Effective
screening could reduce mortality by 10%–30%. Used individually, neither serum CA125 nor …

Introduction: Despite advances in surgery and chemotherapy for ovarian cancer, 70% of
women still succumb to the disease. Biomarkers have contributed to the management of …

Recent studies posit a role for non-coding RNAs in epithelial ovarian cancer (EOC).
Combining small RNA sequencing from 179 human serum samples with a neural network …

Abstract Purpose of Review Both conventional and novel approaches to early detection of
ovarian cancer are reviewed in the context of new developments in our understanding of …

Background CA125 is the best available yet insufficiently sensitive biomarker for early
detection of ovarian cancer. There is a need to identify novel biomarkers, which individually …

The increasing knowledge of the molecular pathogenesis of cancer and the rapid
development of new molecular techniques are promoting the study of early molecular …