Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …

Chemoselective transformations of functionalized sulfonyl fluorides and chlorides are
surveyed comprehensively. It is shown that sulfonyl fluorides provide an excellent selectivity …

The sulfur (VI) fluoride exchange reaction (SuFEx), developed by Sharpless and co-workers
in 2014, is a new category of click reaction that creates molecular connections with absolute …

Application of high-pressure conditions enables enantioselective Michael-type addition of
dialkyl malonates to β-arylethenesulfonyl fluorides. The reaction is efficiently catalyzed with …

An enantioselective conjugate addition of ethylene sulfonyl fluorides to 3-amido-2-oxindoles
has been developed. Quinine-derived squaramides were identified as efficient catalysts. A …

Sulfur (VI) fluoride exchange (SuFEx) is recognized as another emerging tool for click
chemistry. The preparation of the functionalized alkyl sulfonyl fluorides as key SuFEx hubs …

A copper-catalyzed three-component reaction for the transformation of quinolines,
isoquinolines and pyridines to a class of unique indolizine-containing alkyl sulfonyl fluorides …

An enantioselective Michael addition between N-2, 2, 2-trifluoroethylisatin ketimines and
ethylene sulfonyl fluoride has been disclosed. This method provides a facile strategy to …

A (3+2) cycloaddition reaction between substituted vinyl sulfonyl fluorides and ethyl
diazoacetate or azides for the rapid construction of pyrazole or triazole cores via Michael …

Enantioselective conjugate addition of azlactones to ethylene sulfonyl fluoride has been
achieved via the cooperative catalysis with (DHQD) 2PHAL and a hydrogen-bond donor …