Cholangiocarcinoma (CCA) is a malignant tumour arising from the biliary system. In Europe,
this tumour frequently presents as a sporadic cancer in patients without defined risk factors …

Biliary tract cancers (BTCs) are a group of rare and aggressive malignancies that arise in the
biliary tree within and outside the liver. Beyond surgical resection, which is beneficial for …

Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive
phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops …

Simple Summary Despite the enormous advance in biomarker discovery, many potential
biomarkers of drug activity are unable to satisfy the clinical need due to inadequate …

Despite recent advances in targeted therapies and immunotherapies, chemotherapy using
cytotoxic agents remains an indispensable modality in cancer treatment. Recently, there has …

Simple Summary Cholangiocarcinoma, a tumor derived from epithelial cells of the biliary
tree, is characterized by a dismal prognosis. Its late diagnosis, which makes surgical …

The term cholangiocarcinoma (CCA) refers to a heterogeneous group of malignant tumors
generated in different biliary tree locations. This anatomical characteristic is used to classify …

Introduction Chemotherapy is the mainstay of systemic treatment of biliary tract cancer
(BTC). However, the treatment response to chemotherapy varies between patients …

Background The clinical value of heterogeneous sub-populations of circulating tumor cells
(CTCs) in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Methods Peripheral …

Purpose Gemcitabine, the primary drug for the treatment of pancreatobiliary cancer (PBC),
requires human equilibrative nucleoside transporter 1 (hENT1) to enter cells. High tumoral …