Hypertension is the primary cause of cardiovascular diseases (CVD) and is responsible for
nearly 9 million deaths worldwide annually. Increasing evidence indicates that in addition to …

Behavior and function of living systems are synchronized by the 24-h rotation of the Earth
that guides physiology according to time of day. However, when behavior becomes …

Signal perception is a key function in regulating biological activities and adapting to
changing environments. Per-Arnt-Sim (PAS) domains are ubiquitous sensors found in …

Brain and muscle ARNT-like 1 (BMAL1) is a core circadian clock protein and transcription
factor that regulates many physiological functions, including blood pressure (BP). Male …

Background Given that the circadian rhythm is intricately linked to cardiovascular
physiological functions, the objective of this investigation was to employ bibliometric …

BACKGROUND: Despite endothelial dysfunction being an initial step in the development of
hypertension and associated cardiovascular/renal injuries, effective therapeutic strategies to …

Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium
handling in the kidney's collecting duct. Dysregulation of the endothelin axis is associated …

Dysbiosis of the gut microbiota has been implicated in hypertension, and drug–host–
microbiome interactions have drawn considerable attention. However, the influence of …

Circadian rhythms are endogenous biological oscillations that regulate various
physiological processes in organisms, including kidney function. The kidney plays a vital …

Circadian rhythms are crucial for maintaining vascular function and disruption of these
rhythms are associated with negative health outcomes including cardiovascular disease and …