Traditionally considered as a critical intermediate in the toxic and carcinogenic response to
dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor …

Bisphenol A (BPA), as a major component of some plastic products, is abundant
environmental pollutant. Due to its ability to bind to several types of estrogen receptors, it …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

INTRODUCTION Over the past two decades, continuous improvements in “omics”
technologies have driven an ever-greater capacity to define the relationships between …

The goal of systems genetics is to understand the impact of genetic variation across all
levels of biological organization, from mRNAs, proteins, and metabolites, to higher-order …

The aryl hydrocarbon receptor (or AhR) is a cytoplasmic receptor of pollutants. It translocates
into the nucleus upon binding to its ligands, and forms a heterodimer with ARNT (AhR …

Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-
phenome relations in human clinical cohorts. Here we test this approach using a large …

Aryl hydrocarbon receptor (AHR) was initially discovered as a cellular protein involved in
mediating the detoxification of xenobiotic compounds. Extensive research in the past two …

The pool of primordial follicles formed in the ovaries during early development determines
the span and quality of fertility in the reproductive life of a woman. As exposure to …

Aging is the most important risk factor for the development of major life-threatening diseases
such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging …