We detail a six-stage planar differentiation methodology for generating human pluripotent
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …

Improved stem cell-derived pancreatic islet (SC-islet) differentiation protocols robustly
generate insulin-secreting β cells from patient induced pluripotent stem cells (iPSCs). These …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet
organoids could provide an unlimited cell source for diabetes cell replacement therapy …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

The discovery, only a decade ago, of the genome editing power of clustered regularly
interspaced short palindromic repeats (CRISPR)-associated nucleases is already …

Recapitulation of embryonic pancreatic development has enabled development of methods
for in vitro islet cell differentiation using human pluripotent stem cells (hPSCs), which have …

Pancreatic islets regulate blood glucose homeostasis through the controlled release of
insulin; however, current metabolic models of glucose-sensitive insulin secretion are …

Insulin-producing stem cell-derived islets (SC-islets) provide a virtually unlimited cell source
for diabetes cell replacement therapy. While SC-islets are less functional when first …

Regenerative medicine as a field has emerged as a new component of modern medicine
and medical research that encompasses a wide range of products including cellular and …