Herpes simplex virus type 1 and other pathogens are key causative factors in sporadic Alzheimer's disease

SA Harris, EA Harris - Journal of Alzheimer's Disease, 2015 - content.iospress.com
This review focuses on research in epidemiology, neuropathology, molecular biology, and
genetics regarding the hypothesis that pathogens interact with susceptibility genes and are …

Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses

JW Yewdell - Immunity, 2006 - cell.com
Antiviral CD8+ T cells respond to only a minute fraction of the potential peptide determinants
encoded by viral genomes. Immunogenic determinants can be ordered into highly …

Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas

SJ Lin, JA Gagnon-Bartsch, IB Tan, S Earle, L Ruff… - Gut, 2015 - gut.bmj.com
Objective Differences in gastric cancer (GC) clinical outcomes between patients in Asian
and non-Asian countries has been historically attributed to variability in clinical …

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia

P Scheinberg, SH Fischer, L Li, O Nunez, CO Wu… - Blood, 2007 - ashpublications.org
The natural history of EBV and CMV reactivation and the potential for serious complications
following antibody-based immunosuppressive treatment for bone marrow failure syndromes …

Angioimmunoblastic T cell lymphoma: pathobiological insights and clinical implications

K Dunleavy, WH Wilson, ES Jaffe - Current opinion in hematology, 2007 - journals.lww.com
Diseases such as angioimmunoblastic T cell lymphoma can help illuminate the biology of
the normal immune system. Significant progress has been made in understanding the …

LAG3 in gastric cancer: it's complicated

D Ulase, HM Behrens, S Krüger, SM Heckl… - Journal of Cancer …, 2023 - Springer
Purpose Lymphocyte activation gene 3 (LAG3) is thought to contribute to T cell exhaustion
within the tumor microenvironment of solid tumors. This study aimed to analyze the spatial …

Alzheimer's disease and herpes viruses: Current events and perspectives

B Pinchera, I Di Filippo, F Cuccurullo… - Reviews in medical …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a real and current scientific and societal challenge. Alzheimer's
disease is characterised by a neurodegenerative neuroinflammatory process, but the …

Understanding the Mode of Action of a Micro-Immunotherapy Formulation: Pre-Clinical Evidence from the Study of 2LEBV® Active Ingredients

C Jacques, F Marchand, M Chatelais, A Brulefert… - Life, 2024 - mdpi.com
Background: Epstein–Barr virus (EBV) is often kept silent and asymptomatic; however, its
reactivation induces a chronic and/or recurrent infection that is associated with numerous …

Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy

D Adhikary, U Behrends, H Boerschmann, A Pfünder… - PloS one, 2007 - journals.plos.org
Background Epstein-Barr virus (EBV) is associated with a number of human malignancies.
EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic …

Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients

Y Shen, S Zhang, R Sun, T Wu… - Emerging microbes & …, 2015 - Taylor & Francis
Epstein-Barr virus (EBV) has been used as a paradigm for studying host–virus interactions,
not only because of its importance as a human oncogenic virus associated with several …