Uric acid is the final oxidation product of purine metabolism in humans. Xanthine
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric …

Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe
cutaneous adverse drug reactions (SCARs), such as Stevens–Johnson syndrome …

This article has been corrected. The original version (PDF) is appended to this article as a
Supplement. Description: The American College of Physicians (ACP) and the American …

Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a
foundation of an excess body burden of uric acid, manifested in part by hyperuricemia …

Description: The American College of Physicians (ACP) developed this guideline to present
the evidence and provide clinical recommendations on the management of gout. Methods …

Allopurinol is the most commonly prescribed urate-lowering therapy for the management of
gout. Serious adverse reactions associated with allopurinol, while rare, are feared owing to …

Importance Allopurinol, a first-line drug used for treating gout, is increasingly prescribed
worldwide to patients with asymptomatic hyperuricemia and comorbid renal or …

Despite their low frequency, drug hypersensitivity reactions (DHRs) can be serious and
result in lifelong sequelae. The diagnosis is critical to avert future reactions and should …

Background Allopurinol is the primary therapy for the management of chronic gout.
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …

Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator for
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …