This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

We report a systematic review and meta-analysis of studies that assessed the
antinociceptive efficacy of cannabinoids, cannabis-based medicines, and endocannabinoid …

Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

Scientists who perform major survival surgery on laboratory animals face a dual welfare and
methodological challenge: how to choose surgical anesthetics and post-operative …

Simple Summary The 3Rs principle refers to three concepts: Replacement, Reduction and
Refinement. These principles should be taken into consideration during the planning and …

Preclinical studies using animals to study the potential of a therapeutic drug or strategy are
important steps before translation to clinical trials. However, evidence has shown that poor …

Over the last two decades, awareness of the negative repercussions of flaws in the planning,
conduct and reporting of preclinical research involving experimental animals has been …

Neuroactive substances released by activated microglia contribute to hyperexcitability of
spinal dorsal horn neurons in many animal models of chronic pain. An important feedback …

Here we studied spinal neurotransmitter mechanisms involved in the reduction of
mechanical hypersensitivity by inhibition of the amygdaloid central nucleus (CeA) in male …

Clinical trials for rare neuromuscular diseases imply, among other investments, a high
emotional burden for the whole disease community. Translation of data from preclinical …