In silico clinical trials: concepts and early adoptions
Innovations in information and communication technology infuse all branches of science,
including life sciences. Nevertheless, healthcare is historically slow in adopting …
including life sciences. Nevertheless, healthcare is historically slow in adopting …
Multiscale computational modeling of vascular adaptation: a systems biology approach using agent-based models
The widespread incidence of cardiovascular diseases and associated mortality and
morbidity, along with the advent of powerful computational resources, have fostered an …
morbidity, along with the advent of powerful computational resources, have fostered an …
Multiscale modelling and simulation: a position paper
A Hoekstra, B Chopard… - … Transactions of the …, 2014 - royalsocietypublishing.org
We argue that, despite the fact that the field of multiscale modelling and simulation has
enjoyed significant success within the past decade, it still holds many open questions that …
enjoyed significant success within the past decade, it still holds many open questions that …
A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics
In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
A fully coupled computational fluid dynamics–agent-based model of atherosclerotic plaque development: multiscale modeling framework and parameter sensitivity …
Abstract Background Peripheral Artery Disease (PAD) is an atherosclerotic disorder that
leads to impaired lumen patency through intimal hyperplasia and the build-up of plaques …
leads to impaired lumen patency through intimal hyperplasia and the build-up of plaques …
A framework for multi-scale modelling
B Chopard, J Borgdorff… - … Transactions of the …, 2014 - royalsocietypublishing.org
We review a methodology to design, implement and execute multi-scale and multi-science
numerical simulations. We identify important ingredients of multi-scale modelling and give a …
numerical simulations. We identify important ingredients of multi-scale modelling and give a …
[HTML][HTML] Investigating the effect of drug release on in-stent restenosis: a hybrid continuum–agent-based modelling approach
Background and objective In-stent restenosis (ISR) following percutaneous coronary
intervention with drug-eluting stent (DES) implantation remains an unresolved issue, with …
intervention with drug-eluting stent (DES) implantation remains an unresolved issue, with …
Computational modeling of in-stent restenosis: Pharmacokinetic and pharmacodynamic evaluation
Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting
stents warrants the development of highly resolved in silico models. These computational …
stents warrants the development of highly resolved in silico models. These computational …
Multi-scale modeling of the cardiovascular system: disease development, progression, and clinical intervention
Cardiovascular diseases (CVDs) are the leading cause of death in the western world. With
the current development of clinical diagnostics to more accurately measure the extent and …
the current development of clinical diagnostics to more accurately measure the extent and …
Modeling stented coronary arteries: where we are, where to go
S Morlacchi, F Migliavacca - Annals of biomedical engineering, 2013 - Springer
In the last two decades, numerical models have become well-recognized and widely
adopted tools to investigate stenting procedures. Due to limited computational resources …
adopted tools to investigate stenting procedures. Due to limited computational resources …