Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is
the ability for continuous cell divisions that almost universally correlates with the stabilization …

The idea that senescent cells are causally involved in aging has gained strong support from
findings that the removal of such cells alleviates many age‐related diseases and extends …

Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the
irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key …

DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is
based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel …

Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

The naked mole‐rat (Heterocephalus glaber) has fascinated zoologists for at least half a
century. It has also generated considerable biomedical interest not only because of its …

Progressive telomere shortening from cell division (replicative aging) provides a barrier for
human tumor progression. This program is not conserved in laboratory mice, which have …

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

METHODS: LTL was measured in blood samples from 490 newborns and their parents.
RESULTS: LTL (mean±SD) was longer (9.50±0.70 kb) in newborns than in their mothers …