Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver
physiology and fibrogenesis. They are located in the space of Disse and maintain close …

Decompensated liver cirrhosis (LC), a life‐threatening complication of chronic liver disease,
is one of the major indications for liver transplantation. Recently, mesenchymal stem cell …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of
cells with stem cell features (cancer stem cells; CSCs). CSCs are considered a pivotal target …

The unique ability of the liver to regenerate itself has fascinated biologists for years and has
made it the prototype for mammalian organ regeneration. Harnessing this process has great …

Current protocols for differentiation of stem cells make use of multiple treatments of soluble
signals and/or matrix factors and result typically in partial differentiation to mature cells with …

As well as systemic vascular endothelial cells, the liver has specialised sinusoidal
endothelial cells (LSEC). LSEC dysfunction has been documented in many diseased states …

Liver cancers, including hepatocellular carcinomas (HCCs), cholangiocarcinomas (CCs),
and fibrolamellar HCCs (FL‐HCCs) are among the most common cancers worldwide and …

The biliary tree is composed of intrahepatic and extrahepatic bile ducts, lined by mature
epithelial cells called cholangiocytes, and contains peribiliary glands deep within the duct …