Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

Previous studies implicated protein arginine methyltransferase 5 (PRMT5) as a synthetic
lethal target for MTAP-deleted (MTAP del) cancers; however, the pharmacologic …

Epigenetic dysregulation is a common feature of most cancers, often occurring directly
through alteration of epigenetic machinery. Over the last several years, a new generation of …

Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Post-translational modification (PTM) of proteins is vital for increasing proteome diversity
and maintaining cellular homeostasis. If the writing, reading, and removal of modifications …

Type I protein arginine methyltransferases (PRMTs) catalyze asymmetric dimethylation of
arginines on proteins. Type I PRMTs and their substrates have been implicated in human …