[HTML][HTML] Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta …
Purpose: To estimate the strength and shape of the dose–response relationship between
sedentary behaviour and all-cause, cardiovascular disease (CVD) and cancer mortality, and …
sedentary behaviour and all-cause, cardiovascular disease (CVD) and cancer mortality, and …
Axes of a revolution: challenges and promises of big data in healthcare
Health data are increasingly being generated at a massive scale, at various levels of
phenotyping and from different types of resources. Concurrent with recent technological …
phenotyping and from different types of resources. Concurrent with recent technological …
[HTML][HTML] Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …
effects of inherited variation (direct effects), demography (population stratification …
[HTML][HTML] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
[HTML][HTML] Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …
genomic loci across a range of human diseases and traits. However, most biobanks are …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Cohort profile update: the HUNT study, Norway
BO Åsvold, A Langhammer, TA Rehn… - International journal …, 2023 - academic.oup.com
The Trøndelag Health Study (the HUNT Study) is a population-based cohort study of the
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …
[HTML][HTML] Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Estimates from Mendelian randomization studies of unrelated individuals can be biased due
to uncontrolled confounding from familial effects. Here we describe methods for within-family …
to uncontrolled confounding from familial effects. Here we describe methods for within-family …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …