Simple Summary Liquid biopsy has recently been introduced as a novel method in cancer
diagnostics. It is less invasive for patients than conventional tissue biopsies, as the assay …

Based on superior efficacy and tolerability, targeted therapy is currently preferred over
chemotherapy and/or immunotherapy for actionable gene fusions that occur in late‐stage …

PURPOSE A large number of targeted treatment options for stage IV nonsquamous non–
small-cell lung cancer with specific genetic aberrations in tumor DNA is available. It is …

Mechanistically, chimeric genes result from DNA rearrangements and include parts of
preexisting normal genes combined at the genomic junction site. Some rearranged genes …

Oncogenic fusion proteins, arising from chromosomal rearrangements, have emerged as
prominent drivers of tumorigenesis and crucial therapeutic targets in cancer research. In …

Background and Objective: This review comprehensively explores the intricate landscape of
anaplastic lymphoma kinase (ALK), focusing specifically on its pivotal role in non-small cell …

Anaplastic lymphoma kinase (ALK) rearranged non-small-cell lung cancer (NSCLC)
comprises a distinct molecular entity with a reported global prevalence of 5–7%. The …

The detection of ROS1 and ALK rearrangements is performed for advanced-stage non-small
cell lung cancer. Several techniques can be used on cytological samples, such as …

Several observations indicate that protein expression analysis by immunohistochemistry
(IHC) remains relevant in individuals with non-small-cell lung cancer (NSCLC) when …

This study aimed to present a comprehensive assessment of anaplastic lymphoma kinase
(ALK) rearrangements evaluated by DNA/RNA‐based next‐generation sequencing (NGS) …