Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals
FZ Lussier, TA Pascoal, M Chamoun… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Mild behavioral impairment (MBI) is characterized by the emergence of
neuropsychiatric symptoms in elderly persons. Here, we examine the associations between …
neuropsychiatric symptoms in elderly persons. Here, we examine the associations between …
Kinetic isotope effects and synthetic strategies for deuterated carbon-11 and fluorine-18 labelled PET radiopharmaceuticals
MA Klenner, G Pascali, BH Fraser… - Nuclear Medicine and …, 2021 - Elsevier
The deuterium labelling of pharmaceuticals is a useful strategy for altering pharmacokinetic
properties, particularly for improving metabolic resistance. The pharmacological effects of …
properties, particularly for improving metabolic resistance. The pharmacological effects of …
Disclosing tau tangles using PET imaging: a pharmacological review of the radiotracers available in 2021
É Van Wambeke, T Gérard, R Lhommel… - Acta Neurologica …, 2022 - Springer
Neurological symptoms depend on the topography of the lesions in the nervous system,
hence the importance of brain imaging for neurologists. Neurological treatment, however …
hence the importance of brain imaging for neurologists. Neurological treatment, however …
Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer's disease
P Lerdsirisuk, R Harada, Y Hayakawa… - Nuclear Medicine and …, 2021 - Elsevier
Abstract Introduction [18 F] THK-5351 was originally developed as a positron emission
tomography (PET) imaging tracer for the detection of accumulated tau proteins, the …
tomography (PET) imaging tracer for the detection of accumulated tau proteins, the …
Efficient radiosynthesis and preclinical evaluation of [18F]FOMPyD as a positron emission tomography tracer candidate for TrkB/C receptor imaging
TA Singleton, H Bdair, JJ Bailey, S Choi… - Journal of Labelled …, 2020 - Wiley Online Library
Herein we report an efficient radiolabeling of a 18F‐fluorinated derivative of dual inhibitor
GW2580, with its subsequent evaluation as a positron emission tomography (PET) tracer …
GW2580, with its subsequent evaluation as a positron emission tomography (PET) tracer …
Use of capillary electrophoresis for the determination of impurities in preparations of fluorine-18 labelled PET radiopharmaceuticals
D Antuganov, Y Antuganova, T Zykova… - … of Pharmaceutical and …, 2019 - Elsevier
Fluorine-18 labelled radiotracers are the most common diagnostic agents employed in
positron emission tomography (PET). Despite well-established quality control (QC) …
positron emission tomography (PET). Despite well-established quality control (QC) …
Automated production of [18F] MK-6240 on CFN-MPS200
J Toyohara, K Nishino, M Sakai, T Tago… - Applied Radiation and …, 2021 - Elsevier
Automated production of [18 F] MK-6240 was implemented for the first time in the CFN-
MPS200 module. Three consecutive productions of [18 F] MK-6240 complied with the …
MPS200 module. Three consecutive productions of [18 F] MK-6240 complied with the …
Alzheimer's disease pathophysiological correlates of the syndrome of mild behavioral impairment across the spectrum of the disease
F Lussier - 2022 - escholarship.mcgill.ca
Objectives: The development of operationalized research diagnostic criteria for the
syndrome of mild behavioral impairment (MBI) has allowed for the study of the prognostic …
syndrome of mild behavioral impairment (MBI) has allowed for the study of the prognostic …
Alzheimer's Disease Pathophysiological Correlates of the Syndrome of Mild Behavioral Impairment Across the Disease Spectrum
FZ Lussier - 2022 - search.proquest.com
Objectives: The development of operationalized research diagnostic criteria for the
syndrome of mild behavioral impairment (MBI) has allowed for the study of the prognostic …
syndrome of mild behavioral impairment (MBI) has allowed for the study of the prognostic …
High‐yielding, automated radiosynthesis of [11C]martinostat using [11C]methyl triflate
R Hopewell, D Jolly, QY Li, K Ross… - Journal of Labelled …, 2022 - Wiley Online Library
Histone deacetylases (HDACs) mediate epigenetic mechanisms implicated in a broad range
of central nervous system dysfunction, including neurodegenerative diseases and …
of central nervous system dysfunction, including neurodegenerative diseases and …