The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

In both cardiovascular disease and cancer, there are established sex-based differences in
prevalence and outcomes. Males and females may also differ in terms of risk of cardiotoxicity …

During their reproductive years women produce significant levels of estrogens,
predominantly in the form of estradiol, that are thought to play an important role in …

A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Our previous work showed that the G protein-coupled estrogen receptor (GPER) is
protective in the vasculature and kidneys during angiotensin (Ang) II-dependent …

Anthracyclines are the cornerstone for many oncologic treatments, but their cardiotoxicity
has been recognized for several decades. Female subjects, especially before puberty and …

Abstract Ischemic Heart Disease (IHD) is a clinical condition characterized by insufficient
blood flow to the cardiac tissue, and the consequent inappropriate oxygen and nutrients …

Oxidative stress has been implicated in the unfavorable changes in cardiac function and
remodeling that occur after ovarian estrogen loss. Using ovariectomized rat models, we …

G protein-coupled receptors (GPCRs) have been implicated in transmitting signals across
the extra-and intra-cellular compartments, thus allowing environmental stimuli to elicit critical …

Mitochondria are key organelles for the maintenance of myocardial tissue homeostasis,
playing a pivotal role in adenosine triphosphate (ATP) production, calcium signaling, redox …