Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …

Protein-coding and noncoding genes in eukaryotes are typically expressed as linear
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …

Circular RNAs (circRNAs), formed by non-sequential back-splicing of pre-mRNA transcripts,
are a widespread form of non-coding RNA in animal cells. However, it is unclear whether the …

Through alternative processing of pre-messenger RNAs, individual mammalian genes often
produce multiple mRNA and protein isoforms that may have related, distinct or even …

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

Alternative splicing has a crucial role in the generation of biological complexity, and its
misregulation is often involved in human disease. Here we describe the assembly of a …

The precision and complexity of intron removal during pre-mRNA splicing still amazes even
26 years after the discovery that the coding information of metazoan genes is interrupted by …

Lung cancer is the leading cause of cancer-related death worldwide. Aberrant splicing has
been implicated in lung tumorigenesis. However, the functional links between splicing …

Circular RNAs (circRNAs) are single-stranded, covalently closed RNA molecules formed by
mRNA exon back-splicing. Although the circRNA functions remain largely unknown, their …

The myelin‐associated glycoprotein (MAG) is a type I transmembrane glycoprotein localized
in periaxonal Schwann cell and oligodendroglial membranes of myelin sheaths where it …