We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Genome sequencing projects are discovering millions of genetic variants in humans, and
interpretation of their functional effects is essential for understanding the genetic basis of …

Progress in understanding the genetics of human disease is closely tied to technological
developments in DNA sequencing. Recently, next-generation technology has transformed …

RNA sequencing is an increasingly popular technology for genome-wide analysis of
transcript sequence and abundance. However, understanding of the sources of technical …

Recent advances in the understanding of the genetics of type 2 diabetes (T2D) susceptibility
have focused attention on the regulation of transcriptional activity within the pancreatic beta …

Extracellular vesicles (EVs) are the collective term for the various vesicles that are released
by cells into the extracellular space. Such vesicles include exosomes and microvesicles …

The genetics of messenger RNA (mRNA) expression has been extensively studied in
humans and other organisms, but little is known about genetic factors contributing to …

Highlights•Mapping gene expression as a quantitative trait resolves functional regulatory
genetic variants.•Genomic modulators of immune gene expression are typically context …

Obesity and its associated diseases are one of the major causes of death worldwide. The
gut microbiota has been identified to have essential regulatory effects on human metabolism …

MicroRNAs (miRNAs) are critical regulators of gene expression, and their role in a wide
variety of biological processes, including host antimicrobial defense, is increasingly well …