Giant virus biology and diversity in the era of genome-resolved metagenomics

F Schulz, C Abergel, T Woyke - Nature Reviews Microbiology, 2022 - nature.com
The discovery of giant viruses, with capsids as large as some bacteria, megabase-range
genomes and a variety of traits typically found only in cellular organisms, was one of the …

[HTML][HTML] Natural carbon fixation and advances in synthetic engineering for redesigning and creating new fixation pathways

SS Correa, J Schultz, KJ Lauersen… - Journal of Advanced …, 2023 - Elsevier
Background Autotrophic carbon fixation is the primary route through which organic carbon
enters the biosphere, and it is a key step in the biogeochemical carbon cycle. The Calvin …

Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses

M Moniruzzaman, MP Erazo Garcia… - FEMS microbiology …, 2023 - academic.oup.com
The phylum Nucleocytoviricota includes the largest and most complex viruses known. These
“giant viruses” have a long evolutionary history that dates back to the early diversification of …

Metabolic arsenal of giant viruses: Host hijack or self-use?

D Brahim Belhaouari, GA Pires De Souza, DC Lamb… - Elife, 2022 - elifesciences.org
Viruses generally are defined as lacking the fundamental properties of living organisms in
that they do not harbor an energy metabolism system or protein synthesis machinery …

Mitochondria and viral infection: advances and emerging battlefronts

M Sorouri, T Chang, DC Hancks - MBio, 2022 - Am Soc Microbiol
Mitochondria are dynamic organelles vital for energy production with now appreciated roles
in immune defense. During microbial infection, mitochondria serve as signaling hubs to …

Structure–function analysis of an ancient TsaD–TsaC–SUA5–TcdA modular enzyme reveals a prototype of tRNA t6A and ct6A synthetases

M Jin, Z Zhang, Z Yu, W Chen, X Wang… - Nucleic Acids …, 2023 - academic.oup.com
Abstract N 6-threonylcarbamoyladenosine (t6A) is a post-transcriptional modification found
uniquely at position 37 of tRNAs that decipher ANN-codons in the three domains of life …

Amoebae: hiding in plain sight: unappreciated hosts for the very large viruses

VF Queiroz, RAL Rodrigues… - Annual Review of …, 2022 - annualreviews.org
For decades, viruses have been isolated primarily from humans and other organisms.
Interestingly, one of the most complex sides of the virosphere was discovered using free …

Viral complexity

FO Aylward, M Moniruzzaman - Biomolecules, 2022 - mdpi.com
Although traditionally viewed as streamlined and simple, discoveries over the last century
have revealed that viruses can exhibit surprisingly complex physical structures, genomic …

PoRVA G9P [23] and G5P [7] infections differentially promote PEDV replication by reprogramming glutamine metabolism

H Liu, H Tian, P Hao, H Du, K Wang, Y Qiu, X Yin… - PLoS …, 2024 - journals.plos.org
PoRVA and PEDV coinfections are extremely common in clinical practice. Although
coinfections of PoRVA and PEDV are known to result in increased mortality, the underlying …

Giant viruses as a source of novel enzymes for biotechnological application

EG de Oliveira, JVRP Carvalho, BB Botelho… - Pathogens, 2022 - mdpi.com
The global demand for industrial enzymes has been increasing in recent years, and the
search for new sources of these biological products is intense, especially in microorganisms …